Facile Synthesis of Various Nitro-Substituted Derivatives of Semaxinib (SU5416) |
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| Authors: | Torsten Kniess Manuela Kuchar Frank Wuest |
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| Institution: | 1. Institute of Radiopharmacy, Forschungszentrum Dresden-Rossendorf , Dresden, Germany kniess@fzd.de;3. Institute of Radiopharmacy, Forschungszentrum Dresden-Rossendorf , Dresden, Germany |
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| Abstract: | The synthesis of novel nitro-substituted derivatives of the tyrosine kinase inhibitor Semaxinib (SU5416) is described. The reaction of various substituted oxindoles with 3,5-dimethylpyrrol-2-carbaldehyde derivatives under Knoevenagel conditions gave an array of nitro-substituted derivatives of Semaxinib (SU5416) in high yields of 72–87%. |
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| Keywords: | Nitration semaxinib tyrosine kinase |
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