Palladium-Catalyzed Synthesis of Symmetrical Biaryls Under Microwave Irradiation and Conventional Heating |
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| Authors: | Abdol Reza Hajipour Fatemeh Rafiee |
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| Institution: | 1. Pharmaceutical Research Laboratory, Department of Chemistry , Isfahan University of Technology , Isfahan , Iran;2. Department of Pharmacology , University of Wisconsin, Medical School , Madison , Wisconsin , USA haji@cc.iut.ac.ir;4. Pharmaceutical Research Laboratory, Department of Chemistry , Isfahan University of Technology , Isfahan , Iran |
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| Abstract: | The activity of the Pd{C6H4(CH2N(CH2Ph)2)}(µ-Br)]2 complex was investigated in the synthesis of symmetrical biaryls under both conventional and microwave irradiation conditions, and their results were compared. This complex is efficient, stable, and not sensitive to air or moisture and is a catalyst for the homo-coupling reaction of aryl iodides, bromides, and even chlorides. The products were produced in excellent yields in short reaction times using a catalytic amount of Pd{C6H4(CH2N(CH2Ph)2)(µ-Br)]2 complex in N-methylpyrolidine (NMP) at 130 °C. In comparison to conventional heating conditions, the reactions under microwave irradiation gave better yields in shorter reaction times. |
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| Keywords: | Biaryls cyclopalladated catalyst homo-coupling reaction tribenzylamine |
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