Catalyst-free synthesis of novel 4H-indeno[1,2-b]furan-4-ones and furo[2,3-d]pyrimidines in water |
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Authors: | Reyhaneh Khoeiniha Mahnaz Saraei |
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Institution: | Department of Chemistry, Payame Noor University, Tehran, I. R. of Iran |
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Abstract: | An operationally simple, catalyst-free, and efficient protocol for the synthesis of novel 4H-indeno1,2-b]furan-4-one and furo2,3-d]pyrimidine derivatives by a one-pot reaction of 2-aminopyridines, 1,3-indandione, or barbituric acid and phenylglyoxal monohydrate in water at reflux, involving domino aldol condensation, Michael addition, and ring-closing reactions is described. This transformation has several advantages, including high yield, short reaction duration, simple workup, and simple purification. |
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Keywords: | 4H-Indeno[1 2-b]furan-4-one barbituric acid furo[2 3-d]pyrimidine indandione phenylglyoxal monohydrate |
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