Synthesis and characterization of new pyrido-thieno-pyrimidine derivatives incorporating pyrazole moiety |
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| Authors: | Sobhi M Gomha Tamer T El-Idreesy Bazada K A Mabrouk Abdelwahed R Sayed |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypts.m.gomha@gmail.com;3. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt;4. Department of Chemical Engineering, Faculty of Engineering, The British University in Egypt (BUE), El-Shorouk City, Egypt;5. Department of Chemistry, National Institute of Oceanography &6. Fisheries, Cairo, Egypt;7. Department of Chemistry, Faculty of Science, KFU, Al-Ahsa, Saudi Arabia;8. Department of Chemistry, Faculty of Science, University of Beni Suef, Beni Suef, Egypt |
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| Abstract: | 2-Hydrazinyl-pyrido3′,2′:4,5]thieno3,2-d]pyrimidin-4(3H)-one was reacted with commercially available active methylene compounds (e.g., acetylacetone, ethyl acetoacetate, and diethyl malonate) and ethoxymethylenemalononitrile to afford the respective pyrazole derivatives. Moreover, the prepared pyrazolinone was utilized for synthesis of some new arylidene-, arylazo-pyrazolinone, and azolo-triazine derivatives. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, and mass spectral data. |
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| Keywords: | Coupling reactions cyclizations heterocycles heterocyclic amines pyrazoles |
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