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The Preparation of Immunosuppressant SR-31747 |
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| Authors: | Laurence E Burgess |
| Institution: | Central Research Division , Pfizer Inc. , Groton, CT, 06340 |
| Abstract: | The preparation of immunosuppressant SR-31747 is described. Attempts to install the Z-allyl amine included Lindlar partial hydrogenation and vinyl stannane methodologies. Ultimately, the Wittig olefination of aldehyde 12, with the ylide derived from β-aminoethyl phosphonium salt 13 proved successful. |
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