A Convenient and Efficient Process to 5-(2-Di-n-Propylaminoethyl)-6-hydroxyindole |
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| Authors: | Christos G Gourdoupis Heleni K Kotzamani Ionnis K Stamos |
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| Institution: | 1. University of Patras, School of Health Sciences, Department of Pharmacy , Rion, Patras, 261 10, Hellas;2. The National Hellenic Research Foundation , Institute of Organic and Pharmaceutical Chemistry and the Center for Molecular Analysis , 48 V. Konstantinou Ave., Athens, 116 35, Hellas;3. University of Patras, Department of Pharmacy , Rion, Patras, 261 10, Hellas |
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| Abstract: | An intermolecular trapping of the Pummerer intermediate, generated from 9 with TFAA, by 4 at position 5 under mild Lewis acid conditions gave 5. Sequential treatment of 5 with Ra-Ni, LiAlH4 and again Ra-Ni, afforded 8 in high overall yield. |
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| Keywords: | Regioselective reduction pyroglutamic enaminoesters |
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