An efficient one-pot expeditious synthesis of 3-phenyl-1-(6-phenyl-7H-[1,2,4] triazolo[3,4-b] [1,3,4] thiadiazin-3-yl)-1H-pyrazol-5-amines via multicomponent approach |
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| Authors: | Kodam Sujatha Ravindra Pramod Deshpande Rajesh Kumar Kesharwani Phanithi Prakash Babu |
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| Institution: | 1. Department of Chemistry, National Institute of Technology, Warangal, India;2. Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India;3. Department of Advanced Science &4. Technology, NIET, Nims University Rajasthan, Jaipur, India |
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| Abstract: | An efficient synthesis of 3-phenyl-1-(6-phenyl-7H-1,2,4] triazolo3,4-b]1,3,4]thiadiazin-3-yl)-1H-pyrazol-5-amines was accomplished by a simple, atom-economical, and multicomponent approach. Reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol with various phenacyl bromides and benzoylacetonitriles in ethanol and catalytic amount of acetic acid afforded the titled compounds. The structures of newly synthesized compounds were confirmed by their analytical and spectral (IR, 1H-NMR, 13C-NMR, and Mass) data. |
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| Keywords: | Multicomponent reaction phenacyl bromide 3-(2-bromoacetyl)-2H-chromen-2-one triazolothiadiazine |
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