Differences in Dynamics between Crosslinked and Non‐Crosslinked Hyaluronates Measured by using Fast Field‐Cycling Relaxometry |
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| Authors: | Enrico Ravera Marco Fragai Giacomo Parigi Prof Claudio Luchinat |
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| Institution: | CERM and Department of Chemistry “Ugo Schiff”, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino (Italy) |
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| Abstract: | The dynamic properties of water molecules in gels containing linear and crosslinked hyaluronic acid polymers are investigated by using an integrated approach that includes relaxometry, solid‐state NMR spectroscopy, and scanning electron microscopy. A model‐free analysis of field‐dependent nuclear relaxation is applied to obtain information on mobility and the population of different pools of water molecules in the gels. Differences between linear and crosslinked hyaluronic acid polymers are observed, indicating that crosslinking increases both the fraction and the correlation time of water molecules with slow dynamics. |
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| Keywords: | electron microscopy hyaluronates relaxometry viscosupplementation solid‐state NMR spectroscopy |
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