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Cu2+ Effects on Beta-Amyloid Oligomerisation Monitored by the Fluorescence of Intrinsic Tyrosine |
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| Authors: | Abeer Alghamdi Thorben Wellbrock Prof David J S Birch Dr Vladislav Vyshemirsky Dr Olaf J Rolinski |
| Institution: | 1. Department of Physics, University of Strathclyde, Glasgow, G4 0NG UK;2. School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 8QQ UK |
| Abstract: | A non-invasive intrinsic fluorescence sensing of the early stages of Alzheimer's beta amyloid peptide aggregation in the presence of copper ions is reported. By using time-resolved fluorescence techniques the formation of beta amyloid-copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper. |
| Keywords: | Alzheimer's disease beta-amyloid aggregation copper ions protein intrinsic fluorescence time-resolved emission spectra |