|
|||||
|
|
Dual Stimuli-Responsive Controlled Release Nanocarrier for Multidrug Resistance Cancer Therapy |
|
| Authors: | Dr Xiangyu Jiao Zemin Wang Dr Fang Wang Prof Yongqiang Wen |
| Institution: | 1. School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083
These authors contributed equally to this work;2. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 These authors contributed equally to this work;3. School of Light Industry Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353;4. School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083 |
| Abstract: | Multidrug resistance of cancer cells is a major obstacle for cancer chemotherapy. Herein, we present a nanocarrier that can release chemotherapeutic agents to induce tumor cell death and generate NO under NIR to overcome multidrug resistance in cancer chemotherapy. Owing to the unique structure of the water channel in this controlled release system for chemotherapeutic agents, the nanocarrier surface is equipped with more active sites to graft NO donor molecules. The released NO performs very well in reversing multidrug resistance by inhibiting P-gp expression. Our findings provide new insight into multidrug resistance cancer therapy and controlled release nanocarriers for multiple drugs. |
| Keywords: | antitumor agents mesoporous materials multidrug resistance nanotechnology programmable release |