| 八烷氧基萘酞菁锌的激发三重态性质及光动力抗癌活性 |
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| 引用本文： | 吴谊群,陈耐生,黄金陵.八烷氧基萘酞菁锌的激发三重态性质及光动力抗癌活性[J].化学学报,2001,59(4):619-622. |
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| 作者姓名： | 吴谊群 陈耐生 黄金陵 |
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| 作者单位： | 黑龙江大学化学化工学院;福州大学化学系福州大学功能材料研究所 |
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| 摘 要： | 采用激光闪光光解技术测定了系列八烷氧基萘酞菁锌配合物ZnNc(OR)8(R=C4H9,C8H17,C12H25)激发三重态的寿命，研究了该系列化合物光敏化产生单重态氧的能力和对HL60癌细胞的光动力活性，并探讨了它们作为光敏剂在肿瘤光动力治疗中的光敏反应机制。
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| 关 键 词： | 萘P 烷氧基 酞菁 激发态 抗癌活性 光敏化 |
Triplet-state properties and photodynamic anti-cancer activities of zinc octaalkoxy naphthalocynines |
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| Wu Yiqun,Chen Naisheng,Huang Jinling.Triplet-state properties and photodynamic anti-cancer activities of zinc octaalkoxy naphthalocynines[J].Acta Chimica Sinica,2001,59(4):619-622. |
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| Authors: | Wu Yiqun Chen Naisheng Huang Jinling |
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| Abstract: | The triplet-state lifetime of a series of zinc octaalkoxy naphthalocynines ZnNc(OR)8(R=C4H9,C8H17,C12H25) were obtained by Laserflash photolysis. The abilities for photo-generating singlet oxygen and their photodynamic activities against HL60 cancer cell were investigated, and the photosensitization reaction mechanism of the title compounds as photosensitizers in photodynamic therapy was discussed. |
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| Keywords: | NAPHTHALENE P ALKOXYL GROUP PHTHALOCYANIN (=PHTHALOCYANINE) EXCITED STATE ANTINEOPLASTIC ACTIVITY PHOTOSENSITIZATION |
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