N-(3,5-二甲基苯基)氨基甲酸酯单糖及二糖作为高效液相色谱 手性固定相研究

广泛使用的环糊精和多糖手性固定相是由吡喃型葡萄糖结构单元构成, 将D-葡萄糖、D-半乳糖、D-甘露糖、D-木糖、麦芽糖、蔗糖、乳糖、纤维二糖的N-(3,5-二甲基苯基)氨基甲酸酯经过3-异氰酸丙基三乙氧基硅烷键合到硅胶上作为高效液相色谱的手性固定相, 结果表明它们也具有好的手性分离能力, 并且它们之间的手性识别能力还具有好的互补性. 该研究表明, 在高效液相色谱中寡糖能成为一类新型的手性固定相.

N-(3,5-Dimethylphenyl)carbamate of Mono- and Di-saccharide Used as Chiral Stationary Phases in HPLC

Cyclodextrin and polysaccharide derivatives that consist of glucopyranose units have been ex-tensively used as chromatographic chiral stationary phases. The enantioseparations were examined using N-(3,5-dimethylphenyl)carbamates of glucose, galactose, mannose, xylose, maltose, sucrose, lactose and cellobiose as chiral selector bonded to silica gel via an arm in HPLC. Surprisingly, they also possess good enantioseparation selectivity, and there is a big chiral discriminating complementarity. This work indicates that oligosaccharides derivatives can soon become very attractive as a new kind of chiral stationary phase for HPLC.