| 海藻酸钙-壳聚糖微胶囊组成对BSA通透性能影响的研究 |
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| 引用本文： | 邢楠,田丰,刘圣军,杨健,陈世谦,赵永亮.海藻酸钙-壳聚糖微胶囊组成对BSA通透性能影响的研究[J].化学学报,2007,65(24):2952-2958. |
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| 作者姓名： | 邢楠 田丰 刘圣军 杨健 陈世谦 赵永亮 |
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| 作者单位： | (军事医学科学院卫生装备研究所 天津 300161) |
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| 基金项目： | 解放军医药卫生科研项目 |
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| 摘 要： | 对海藻酸钙-壳聚糖微胶囊的牛血清白蛋白(BSA)双向通透性能进行了定量和定性的初步研究, 并初步考察了微胶囊的组成成分及海藻酸钠、壳聚糖的溶液浓度对BSA通透性能的影响. 结果表明海藻酸钙-壳聚糖微胶囊在pH 1.5～2.0时通透性减弱, pH 6.8时通透性增强, 且海藻酸钙微胶囊通透性大于海藻酸钙-壳聚糖微胶囊; 海藻酸钙-壳聚糖微胶囊中壳聚糖浓度越小, 通透性越好; 海藻酸钠浓度的影响不显著.
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| 关 键 词： | 海藻酸钙-壳聚糖 微胶囊 牛血清白蛋白(BSA) 双向 通透性 |
| 收稿时间： | 2007-01-10 |
| 修稿时间： | 2007-08-23 |
Study on the Effect of Composition of Calcium Alginate-Chitosan Microcapsule on BSA Permeability |
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| XING Nan,TIAN Feng,LIU Sheng-Jun,YANG Jian,CHEN Shi-Qian,ZHAO Yong-Liang.Study on the Effect of Composition of Calcium Alginate-Chitosan Microcapsule on BSA Permeability[J].Acta Chimica Sinica,2007,65(24):2952-2958. |
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| Authors: | XING Nan TIAN Feng LIU Sheng-Jun YANG Jian CHEN Shi-Qian ZHAO Yong-Liang |
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| Institution: | (Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin 300161) |
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| Abstract: | Bovine serum albumin (BSA) bidirectional permeability of calcium alginate-chitosan microcap-sules was investigated by quantitative and qualitative researches. The effects of composition of the micro-capsules and concentrations of alginate and chitosan were studied. The results show that BSA permeability of the microcapsules decreases when pH is 1.5 to 2.0,whereas increases when pH is 6.8. Permeability of the calcium alginate microcapsules is better than that of the calcium alginate-chitosan microcapsules,and for the calcium alginate-chitosan microcapsules the lower the concentration of chitosan is,the higher the permeabil-ity is. The effect of concentration of alginate is not obvious. |
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| Keywords: | calcium alginate-chitosan microcapsule bovine serum albumin (BSA) bidirectional perme-ability |
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