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三核铜配合物[Cu_3L_2](ClO_4)_2(H_2L=1,3-双(2-羟基-1-苯基-亚甲基)-丙烷)的合成与对pBR322DNA的切断作用
引用本文:沈鹤柏,杨永桃,杨仕平,蒯丽衡,姜霁,陈红梅.三核铜配合物[Cu_3L_2](ClO_4)_2(H_2L=1,3-双(2-羟基-1-苯基-亚甲基)-丙烷)的合成与对pBR322DNA的切断作用[J].化学学报,2003,61(12):2029-2032.
作者姓名:沈鹤柏  杨永桃  杨仕平  蒯丽衡  姜霁  陈红梅
作者单位:上海师范大学生命与环境科学学院,上海,200234
基金项目:上海市自然科学基金(No.02ZA14068)、上海市科委科技攻关(No.011511021)资助项目.
摘    要:利用席夫碱配体H_2L = 1,3-双(2-羟基-1-苯基-亚甲基)-丙烷]与铜盐作 用,得到了配合物Cu_3L_2](ClO_4)_2,并用X射线单晶衍射测定了其晶体结构。 研究了该三核铜配合物与质粒pBR322 DNA之间的相互作用,琼脂糖凝胶电泳实验结 果表明该配合物能够将pBR322 DNA从超螺旋构型切割成开环型和线型。同时,紫外 光谱实验可以推测,配合物在对pBR322 DNA进行切断时,它们之间在一种插入作用 。

关 键 词:铜络合物  席夫碱  X射线衍射分析  晶体结构  紫外分光光度法
修稿时间:2003年3月31日

Synthesis of Trinuclear Copper (II) Complex [Cu_3L_2] (ClO_4)_2 and Its Cleavage of pBR332 DNA
SHEN,He-Bai YANG,Yong-Tao YANG,Shi-Ping KUAI,Li-Heng JIANG,Ji CHEN,Hong-Mei.Synthesis of Trinuclear Copper (II) Complex [Cu_3L_2] (ClO_4)_2 and Its Cleavage of pBR332 DNA[J].Acta Chimica Sinica,2003,61(12):2029-2032.
Authors:SHEN  He-Bai YANG  Yong-Tao YANG  Shi-Ping KUAI  Li-Heng JIANG  Ji CHEN  Hong-Mei
Institution:College of Life and Environment Science, Shanghai Normal University
Abstract:A trinudear copper (II) complex with Schiff-base ligand, Cu_3L_2] (ClO_4)_2, H_2L = 1,3-bis(2-hydroxylbenzoylimino)propane], was synthesized and characterized by X-ray crystal diffraction analysis. The interaction of the complex with pBR322 DNA has been investigated by agaiose gel electrophoresis. The complex has been found to promote cleavage of pBR322 DNA from supercoiled form I to the open circular form II and to linearized form III , showing that the complex has high cleaving efficiency to DNA. The UV spectroscopy demonstrates that the complex can bind to DNA by partial intercalation.
Keywords:trinuclear copper complex  pBR322 DNA  cleavage  agarose gel electrophoresis
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