N, N'-二取代二硫代草酰胺与二元胺反应的研究

本文研究了N, N'-二取代二硫代草酰胺与二元胺(乙二胺、1, 3-丙二胺、反-1,2-环己二胺)在二甲基亚矾中的反应。用IR、^1H NMR和四圆衍射法测定了产物的结构。实验结果表明, 反应存在着两种方式, 一种是二元胺的两个氨基反应在同一个硫代酰基的碳原子上(如乙二胺、1, 3-丙二胺)。而另一种由于立体的影响,反应在两个相邻硫代酰基的两个碳原子上(如反-1, 2-环己二胺)。

Studies of the reactions between N, N'-disubstituted thioxamide and diamines

The reactions between N, N'-disubstituted thioxamide and diamines (1,2-diaminoethane, 1,3-diaminopropane, trans-1,2-diaminocyclohexane) are studied. Various products are obtained from different diamines. The structures of the products are confirmed by IR, 1HNMR and x-ray diffraction study. There exist two kinds of reactions, one is that amino groups of diamines react with the same carbon atom of N,N'-disubstituted thioxamides, the other is that two amino groups react with different carbon of the thioxamides. E.g., reaction of thioxamide I with 1,3-diaminopropane at 20-30?gave 63% hydropyrimidine II, while reaction of I with 1,3-diaminopropane at 50?gave 54% hydrobipyrimidine III.