2,8-二氨基-10-甲氧基-5,10-二氢磷杂吖嗪-10-氧化物的合成、诱变性及应用性能研究

10-羟基-5，10-二氢磷杂吖嗪-10-氧化物(1)经酰氯化、甲基化得到10-甲氧基-5，10-二氢磷杂吖嗪-10-氧化物(2)，2经硝化得到10-甲氧基-2，8-二硝基，5，10-二氢磷杂吖嗪-10-氧化物(3.62％)．3在Pd／C(u=0．05)存在下，用氢气还原为2，8-二氨基-10-甲氧基-5，10-二氢磷杂吖嗪-10-氧化物(4.71％)，考察了Bd／C(w=0．05)用量对氢化还原反应的影响．经过Salmonella／mammalian microsome assay测试，4表现为非诱变性，用4与乙酰J-酸作用得到新型双偶氮酸性染料(5)．5对羊毛和丝绸分别在2％与3％色度下浸染郜得到黑色染样，考察了5的上染曲线，并对染样进行了测色研究，发现该染料属于酸性蓝黑染料，其黑度优于目前市场上流行的酸性黑10B．

Syntheses, Mutagenicity and Applied Performance of 2,8-Diamino-10-methoxy- 5,10-dihydrophenophosphazine 10-Oxide

Hydroxy 5,10 dihydrophenophosphazine 10 oxide (1) reacted with SOCl 2, and then with MeONa in MeOH to give a methyl phosphinate (2) which can be converted to a dinitro compound 3 (62%) by nitration and the resulting dinitro compound 3 can further be converted to 2,8 diamino 10 methoxy 5,10 dihydrophenophosphazine 10 oxide (4, 71%) by hydrogenation over Pd/C ( w =0 05). And the effect of amount of Pd/C ( w =0 05) on the reduction was also studied.This nonmutagenic amino compound 4 (via the investigation into Salmonella/mammalian microsome assay) was also employed as diazo moiety coupling with acet J acid to form a diazo acid dye 5.The new dye 5 can color wool at 2% or silk at 3% o.w.f. into black one. The investigation of the uptake of 5 and its color appearance showed that it was assigned to an acid bluish black dye and its blackness was more excellent than that of Acid Black 10B.