| 手性噻唑烷-铑(I)配合物催化的苯乙酮不对称硅氢化反应 |
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| 引用本文： | 李弘,姚金水,何炳林.手性噻唑烷-铑(I)配合物催化的苯乙酮不对称硅氢化反应[J].化学学报,1998,56(2):189-193. |
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| 作者姓名： | 李弘 姚金水 何炳林 |
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| 作者单位： | 南开大学吸附与分离功能高分子材料国家重点;南开大学高分子化学研究所 |
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| 摘 要： | 由L-半胱氨酸甲酯与α-吡啶甲醛缩合制备了2-(α-吡啶基)-4-羧甲基-1, 3-噻唑烷手性配体。用该手性配体与Rh(COD)]2反应原位生成的Rh(I)配合物为催化剂进行了苯乙酮的不对称硅氢化反应。反应的化学产率达91%, 光学产率达82.1%e.e.。考察了各种反应条件对催化剂性能的影响。
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| 关 键 词： | 吡啶P 噻唑P 缩合反应 催化 苯乙酮 铑络合物 甲醛P 硅氢化反应 半胱氨酸甲酯 |
| 修稿时间： | 1996年7月12日 |
Asymmetric hydrosilation of acetophenone catalyzed by a chiral thiazolidine-rhodium(I) complex |
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| LI Hong YAO Jin - Shui HE Bing - Lin.Asymmetric hydrosilation of acetophenone catalyzed by a chiral thiazolidine-rhodium(I) complex[J].Acta Chimica Sinica,1998,56(2):189-193. |
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| Authors: | LI Hong YAO Jin - Shui HE Bing - Lin |
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| Abstract: | A chiral ligand of 2-(α-pyridyl)-4-carbomethoxy-1, 3-thiazolidine was synthesized by condensation of L-methyl cysteinate with α-pyridylaldehye. The Rh(I) complex generated in situ by reaction of the chiral ligand with Rh(COD)]2 was used to catalyze the asymmetric hydrosilation of acetophenone. The chemical and optical yields of the reaction are up to 91% and 82.1% e.e. respectively. The influences of reaction conditions on the behaviour of the catalyst were examined. |
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| Keywords: | asymmetric hydrosilation chiral thiazolidine acetophnone rhodium |
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