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维生素C溶液有氧降解动力学
引用本文:史焱,詹先成,吕太平,马烈,曹呈勇,舒晓明,李成容,李琳丽,何宁.维生素C溶液有氧降解动力学[J].化学学报,2006,64(11):1189-1194.
作者姓名:史焱  詹先成  吕太平  马烈  曹呈勇  舒晓明  李成容  李琳丽  何宁
作者单位:靶向药物教育部重点实验室,四川大学华西药学院,成都,610041
摘    要:建立了一种恒温高压氧药物稳定性加速试验方法, 用这种方法可在较短的时间内求得药物氧化反应的动力学参数. 以10%维生素C溶液为例, 维生素C在有氧和无氧条件下均可降解, 总的降解速率常数kt由两部分构成: ktkankae, kan为无氧降解速率常数, 可表达为kanAan•exp(-Ea,an /RT); kae为有氧降解速率常数, 可表达为kaeAae•exp(-Ea,ae/ RT)• .

关 键 词:恒温高压氧加速试验  药物稳定性  降解动力学    维生素C
收稿时间:08 26 2005 12:00AM
修稿时间:2005-08-262006-04-10

Kinetic Studies on the Oxidative Degradation of Vitamin C Solution
SHI,Yan,ZHAN,Xian-Cheng,L,Tai-Ping,MA,Lie,CAO,Cheng-Yong,SHU,Xiao-Ming,LI,Cheng-Rong,LI,Lin-Li,HE,Ning.Kinetic Studies on the Oxidative Degradation of Vitamin C Solution[J].Acta Chimica Sinica,2006,64(11):1189-1194.
Authors:SHI  Yan  ZHAN  Xian-Cheng  L  Tai-Ping  MA  Lie  CAO  Cheng-Yong  SHU  Xiao-Ming  LI  Cheng-Rong  LI  Lin-Li  HE  Ning
Institution:(Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041)
Abstract:An isothermal experiment with high pressure oxygen was established. The stability of 10% vitamin C solution as a model drug was studied and the kinetics parameters were obtained in a short time with the newly established experimental method. Because vitamin C degrades in both anaerobic and aerobic conditions, the total rate constant kt can be expressed as: ktkankae, where kan and kae are the anaerobic and aerobic degradation rate constants, respectively. The kan can be expressed as kanAan•exp(-Ea,an/RT) according to Arrhenius equation, and the kae was found to be kaeAae•exp(-Ea,ae/RT)• in our experiments.
Keywords:isothermal experiment with high pressure oxygen  drug stability  degradation kinetics  oxygen  vitamin C  
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