脂质体中不同种类羧酸钾对草酸钙晶体生长的调控作用

首次研究了狼磷脂-水脂质体中不同种类羧酯钾对草酸钙晶体生长的调控作用 。加入一元DAc只诱导一水草酸钙（COM）生成。二元K_2tart在其浓度大于1. 0mmol/L时可以诱导三水草酸钙（COT）生成。而加入三元的K_3cit和四元的 K_2edta后， 在不同的浓度下，可以分别诱导COM，二水草酸钙（COD）和COT的生 成。在低浓度（—3.3-17mmol/L）范围，， COD含量达到100%；而在较高浓度(＞ 17mmol/L)时，COD减少，COT含量增加。在不同的浓度区间，无论是COM含量减少， 还是COT含量增加，或者是COD含量的先增加后减少，均与该羧酸钾浓度的对数呈线 性关系。不同羧酯钾抑制COM生长并诱导COD形成的能力顺序为：K_3cit＞K_2edta ＞＞K_2tart-KAC,诱导COT生长的能力顺序为：K_2tart＞＞K_3cit＞K_2edta＞＞ KAc.由此推测抑制草酸钙结石形成的潜在效率依次为：K_3cit＞K_2edta＞＞ K_2tart＞＞KAc.

Effects of Different Kinds of Potassium Carboxylates on the Growth of Calcium Oxalate Crystals in Lecithin-Water Liposomes

The effects of different kinds of potassium carboxylates on the phase compositions of calcium oxalate (CaOxa) crystals grown in lecithin-water liposomes were first reported. The investigated potassium carboxylates included: monocarboxylate potassium acetate ( KAc), dicarboxylate potassium tartrate ( K_2tart) , tricarboxylate potassium citrate (K_3cit), and tetracarboxylate dipotassium of ethylenediaminetetraacetic acid (K_2edta). KAc only induces calcium oxalate monohydrate (COM) . Calcium oxalate trihydrate (COT) was induced when concentrations of K_2tart > 1.0 mmol/L. K_3cit and K_2edta can induce COM, calcium oxalate dihydrate (COD) and COT crystals depending on their concentrations. In a lower concentration range (1.0 ~ 17 mmol/L) , the COM content decreased and the COD content increased with increasing concentration of the K_3cit or K_2edta in logarithmic fashion. In a medium concentration range (3.3 to 17 mmol/L), only COD was grown. In a higher concentration range ( > 17 mmol/L) , COT was nucleated. The ability to induce COD follows the order: K_3cit > K_2edta > > K_2tart ~ KAc, and the ability to induce COT follows: K_2tart > > K3_cit > K_2edta > > KAc. Since the affinity of calcium oxalate hydrates to the membranes of renal tubule cells follows: COM > COT > COD, that is, COD is easily expelled from human body along with urine. So the inhibitory efficiency of potassium carboxylates on CaOxa stones can be deduced as K_3cit > K_2edta > > K_2tart > > KAc.