配合物[Ni(EDTB)]•2Cl•CH3OH•C2H5OH的合成、晶体结构及SOD模拟活性的研究

报道六齿配体N,N,N',N'-四(2-苯并咪唑亚甲基)-1,2-乙二胺(EDTB)及单核镍(II)配合物Ni(EDTB)]•2Cl• CH₃OH•C₂H₅OH的合成、晶体结构和SOD模拟活性. 该配合物为三斜晶系, P1空间群, a＝1.0931(2) nm, b＝1.1693(2) nm, c＝1.6756(4) nm, α＝76.042(3)°, β＝88.787(3)°, γ＝72.044(3)°, V＝1.9740(7) nm³, D_c＝1.321 g/cm³, Z＝2, F(000)＝824, μ＝0.670 mm^－1. 最终因子RI＞2σ(I)]: R₁＝0.0611, wR₂＝0.1497; R(全部数据): R₁＝0.0870, wR₂＝0.1604. 结构分析表明, 镍(II)分别与配体中的四个苯并咪唑氮和两个亚胺基氮配位形成扭曲的八面体构型. 改良的邻苯三酚自氧化活性测定表明, 该配合物具有较高的SOD模拟活性.

Synthesis and Crystal Structure of Complex Ni(EDTB)•2Cl•CH3OH•C2H5OH and Its Superoxide Dismutase Mimic Activity

The title complex Ni(EDTB)•2Cl•CH₃OH•C₂H₅OH EDTB＝N,N,N',N'-tetrakis-(2-benzimi- dazolyl)methyl]-1,2-ethanediamine] has been synthesized and characterized by elemental analysis and single crystal X-ray diffraction method. The crystal of mononuclear Ni(II) complex belongs to triclinic system with space group, P1, a＝1.0931(2) nm, b＝1.1693(2) nm, c＝1.6756(4) nm, α＝76.042(3)°, β＝88.787(3)°, γ＝72.044(3)°, V＝1.9740(7) nm³, D_c＝1.321 g/cm³, Z＝2, F(000)＝824, μ＝0.670 mm^－1. The final RI＞2σ(I)]: R₁＝0.0611, wR₂＝0.1497 and R (all data): R₁＝0.0870, wR₂＝0.1604. The nickel(II) atom of the cation has distorted octahedral coordination geometry and is six-coordinated by six nitrogen atoms: four nitrogen atoms of the benzimidazole groups and two tertiary amine nitrogen atoms from the ligand. The superoxide dismutase mimic activity of the complex has been determined by means of modified Marklund method to show that the title complex has a high superoxide dismutase mimic activity.