用于癌症病人初级临床诊断的化学计量学研究 |
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引用本文: | 王小如,朱尔一,颜晓梅,杨 原,黄本立,庄峙厦.用于癌症病人初级临床诊断的化学计量学研究[J].化学学报,1993,51(11):1094-1098. |
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作者姓名: | 王小如 朱尔一 颜晓梅 杨 原 黄本立 庄峙厦 |
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作者单位: | 厦门大学化学系分析研究所,厦门大学化学系分析研究所,厦门大学化学系分析研究所,厦门大学化学系分析研究所,厦门大学化学系分析研究所,厦门大学环境科学研究中心 厦门 361005,厦门 361005,厦门 361005,厦门 361005,厦门 361005,厦门 361005 |
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基金项目: | 国家教委优秀青年教师基金,国家自然科学基金,国家教委归国留学生启动基金,福建省自然科学基金,国家人事部博士后基金 |
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摘 要: | 用感应耦合等离子体原子发射光谱及石墨炉原子吸收测定了正常人及癌症病人头发与血清样品中13个元素。将所得数据送入计算机, 分别用化学计量学中PLS及Gram-Schmidt多元分析方法处理了血清与头发样本。在两种情况下均得到了病人与正常人分类极其清晰的二维判别图。头发样本的判别失误率低于血清样本。头发样品取样、存储及运输容易, 也宜于进行光谱分析, 因此可将头发用作癌症初级临床诊断中的分析样品。
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关 键 词: | 诊断 原子吸收分光光度法 癌 头发 石墨化炉 血清 电感耦合等离子体 原子发射光谱 化学计量学 |
Chemometrics study on preliminary clinical diagnostics for cancer patients |
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Abstract: | Multielements in normal people's and cancer patient's hair and serum samples were simultaneously determine with inductively coupled plasma-at. emission spectrometry (ICP-AES). The trace amount of Se in hair and serum was determine with a graphite furnace atomic absorption spectrometer (GF-AAS). The experimental results obtained were then studied with the chemometric technique. Both partial least squares (PLS) and Gram-Schmid methods were applied to the classification of normal people and cancer patients. The technique developed is considered to be used as a preliminary clin. diagnostic method for cancer patients. Hair samples are preferred as the analyte due to their easy sampling, treatment, storage as well as transportation. |
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Keywords: | DIAGNOSIS ATOMIC ABSORPTION SPECTROPHOTOMETRY CARCINOMA HUMAN HAIR GRAPHITIZING FURNACES SERUM ICP ATOMIC EMISSION SPECTROMETRY STOICHIOMETRY |
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