基于HPMCP包覆介孔SBA-15的pH敏感药物缓释系统

以肠溶性包衣材料羟丙甲纤维素邻苯二甲酸酯(HPMCP)为原料，在负载法莫替丁(Famo)的SBA-15药片表面包覆聚合物膜，成功制备了一种新型的pH敏感药物缓释系统, 并考察了此缓释系统在不同pH释放环境中的释放行为. 结果表明: 在模拟胃液中(SGF, pH=1.2)，HPMCP能致密包覆在药片表面，从而明显延缓Famo的释放速度；而在模拟肠液中(SIF, pH=7.5)，HPMCP能够迅速溶于缓释溶液中，因而对Famo释放速度的影响甚微. 因此，可以将这种新型智能药物缓释系统应用于肠道靶向给药.

SBA-15 Tablet Coated with HPMCP for pH-Sensitive Drug Release System

A novel pH-sensitive drug release system was fabricated by coating hydroxypropyl methylcellulose phthalate (HPMCP) on a drug-loaded SBA-15 tablet. Two kinds of release media, including simulated gastric fluid (SGF, pH＝1.2) and simulated intestinal fluid (SIF, pH＝7.5), were used to study the different drug release behavior of the system SBA-15/HPMCP. In SGF, due to the compact HPMCP coating on the SBA-15 tablet, the coating material could effectively delay the release rate of famotidine (Famo). But in SIF, because HPMCP could be quickly dissolved into the release medium, no obvious effect of the coating material on the drug delivery rate was found. Therefore, this novel system would have a potential application to targeting intestinal drug release.