九子参中三个糖链上带乙酰基的新三萜皂苷-九子参苷B, C, D

从石竹科植物九子参(Silene rubicunda)根中得到四个糖链上带乙酰基的新的三萜皂苷-九子参苷A, B, C, D(rubicunosides A~D, 1~4)。前文已详细报道了九子参苷A的结构研究, 本文报道九子参苷B, C, D的结构。通过FAB-MS和NMR,分别确定九子参苷B, C, D为糖链上带单乙酰基的三萜九糖苷、七糖苷和糖链上带双乙酰基的三萜八糖苷, 分别命名为皂树酸-3-O-β-D-吡喃半乳糖-(1→2)-β-D-吡喃木糖-(1→3)]-β-D-吡喃葡萄糖醛酸-28-O-β-D-吡喃木糖-(1→3)-β-D-吡喃木糖-(1→4)-α-L-吡喃鼠李糖-(1→4)-β-D-吡喃葡萄糖-(1→4')-β-D-吡喃鸡纳糖-(1→2)]-3'-O-乙酰基]-β-D-吡喃夫糖苷(九子参苷B, 2), 皂树酸-3-O-β-D-吡喃半乳糖-(1→2)-β-D-吡喃木糖-(1→3)]-β-D-吡喃萄淘糖醛酸-28-O-β-D-吡喃木糖-(1→4)-α-L-吡喃鼠李糖-(1→4)-4"-O-乙酰基-β-D-吡喃葡萄糖-(1→2)]-β-D-吡喃夫糖苷(九子参苷C, 3), 皂树酸-3-O-β-D－吡喃半乳糖-(1→2)-β-D-吡喃半乳糖-(1→2)-β-D-吡喃木糖-(1→3)]-6'-O-正丁基]-β-D-吡喃葡萄糖醛酸-28-O-β-D-吡喃木糖-(1→3)-β-D-吡喃木糖-(1→4)-α-L-吡喃鼠李糖-(1→4)-2"-O-乙酰基-β-D-吡喃鸡纳糖-(3'-O-乙酰基]-β-D-吡喃夫糖苷(九子参苷D, 4)。

Rubicunosides B, C, D-three new triterpenoids saponins with acetylated saccharides from silene rubicunda

Three new triterpenoid saponins with acetylated saccharides, named rubicunosides B(2), C(3), D(4), were isolated from the roots of Silene rubicunda and characterized on the basis of spectral evidence as 3-O- β-D-galactopyranosyl-(1→2)-β-D-xylopyranosyl-(1→3)]-β-D- glucuronopyranosyl quillaic acid 28-O-β-D-xylopyranosyl-(1→3)-β-D- xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl- (1→4')-β-D-quinovopyranosyl-(1→2)]-3'-OAc]-β-D-fucopyranoside (2), 3-O-β-D-galactopyranosyl-(1→2)-β-D-xylopyranosyl-(1→3)]-β-D -glucuronopyranosyl quillaic acid 28-O-β-D-xylopyranosyl-(1→4)-α-L- rhamnopyranosyl-(1→4)-4"-OAc-β-D-glucopyranosyl-(1→2)]-β-D- Afucopyranoside (3), and 3-O-β-D-galactopyranosyl-(1→2)-β-D- xylopyranosyl-(1→3)]-6'-O-n-butyl]-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-xylopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L- rhamnopyranosyl-(1→4)-2"-OAc-β-D-quinovopyranosyl-(1→2)]-3'-OAc]- β-D-fucopyranoside (4), respectively.