| 配合物[RE2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O的合成、 晶体结构及其与DNA作用方式初探 |
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| 引用本文： | 陈凤英a,b 何水样,a 刘 峰a 王刘杰a.配合物[RE2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O的合成、 晶体结构及其与DNA作用方式初探[J].化学学报,2009,67(6):555-563. |
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| 作者姓名： | 陈凤英a b 何水样 a 刘 峰a 王刘杰a |
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| 作者单位： | (a西北大学化学系 陕西省物理无机化学重点实验室 西安 710069) ;(b商洛学院化学系 商洛 726000) ; |
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| 摘 要： | 以N-(2-异丙酸)-邻羟基苯甲酰腙(C10H10N2O4, H3L)、2,6-吡啶二甲酸(2,6-H2PDA)与RE(NO3)3•nH2O (RE＝Pr, Eu)在室温下反应, 合成了配合物1 Pr2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O和配合物2 Eu2(H2L)2(HL)2(2,6-H2PDA)- (H2O)2]•2H2O, 对其进行了元素分析、红外光谱、紫外光谱等表征, 测定了两种配合物的晶体结构. 通过紫外吸收光谱、荧光发射光谱和稳态荧光猝灭方法及其与溴化乙锭(EB)的竞争实验研究了两种配合物与小牛胸腺DNA的作用情况. 结果表明, 两种配合物与小牛胸腺DNA均是以插入方式结合的.
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| 关 键 词： | 稀土 N-(2-异丙酸)-邻羟基苯甲酰腙 2 6-吡啶二甲酸 晶体结构 小牛胸腺DNA |
| 收稿时间： | 2008-5-12 |
| 修稿时间： | 2008-11-21 |
Synthesis, Crystal Structure and Preliminary DNA-binding Studies of [RE2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O |
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| Institution: | (a Shaanxi Key Laboratory of Physico-inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an 710069)
(b Department of Chemistry, Shangluo University, Shangluo 726000)
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| Abstract: | Complex 1 Pr2(H2L)2(HL)2(2,6-H2PDA)(H2O)2]•2H2O and complex 2 Eu2(H2L)2(HL)2(2,6- H2PDA)(H2O)2]•2H2O were obtained by reactions of N-(2-propionic acid)-salicyloyl hydrazone (C10H10N2O4, H3L), 2,6-pyridinedicarboxylic acid (2,6-H2PDA) and RE(NO3)3•nH2O (RE＝Pr, Eu) at room temperature, and characterized by elemental analyses, IR, UV, and single crystal X-ray diffractometry. In addition, the DNA binding properties of the two complexes were studied by means of UV absorption spectrum, emission spectroscopic spectrum, steady-state emission quenching and DNA competitive binding with ethidium bromide (EB). The results indicated that the two complexes bound to calf-thymus DNA in an intercalative mode. |
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| Keywords: | rare earth N-(2-propionic acid)-salicyloyl hydrazone 2 6-pyridinedicarboxylic acid crystal structure calf-thymus DNA |
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