| 柔红霉素修饰的纳米金电极的制备及其对DNA检测 |
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| 引用本文： | 郑华,胡劲波,李启隆.柔红霉素修饰的纳米金电极的制备及其对DNA检测[J].化学学报,2006,64(8):806-810. |
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| 作者姓名： | 郑华 胡劲波 李启隆 |
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| 作者单位： | (北京师范大学化学系 北京 100875) |
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| 摘 要： | 利用双硫醇分子作为连接剂, 将纳米金颗粒固定于金电极上, 用伏安法、紫外-可见光谱和电化学交流阻抗对其组装过程以及活性进行了表征. 制备的纳米金修饰电极用于DNA测定及其对DNA损伤的检测. DNA的检测限为 1.2×10－9 mol/L. 该法灵敏、简便.
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| 关 键 词： | 纳米金 柔红霉素 DNA |
| 收稿时间： | 07 1 2005 12:00AM |
| 修稿时间： | 2005-07-012005-10-24 |
Preparation of Daunomycin Modified Nano Gold Electrode and, Its Application to Detection of DNA |
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| ZHENG,Hua,HU,Jing-Bo,LI,Qi-Long.Preparation of Daunomycin Modified Nano Gold Electrode and, Its Application to Detection of DNA[J].Acta Chimica Sinica,2006,64(8):806-810. |
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| Authors: | ZHENG Hua HU Jing-Bo LI Qi-Long |
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| Institution: | (Department of Chemistry, Beijing Normal University, Beijing 100875) |
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| Abstract: | The modification of gold electrode with gold nanoparticles by chemical adsorption of 1,6-hexanedithiol was achieved. The preparation process and activity of this interface were characterized with voltammetry, UV-Vis spectroscopy and electrochemical impedance spectroscopy. The modified electrode was used to detect DNA and the damage of DNA, with the detection limit of DNA to be 1.2×10－9 mol/L. This method is sensitive and convenient. |
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| Keywords: | gold nanoparticle daunomycin DNA |
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