七-(2,6-二-O-甲基)-β-环糊精对1,1'-联萘酚对映体手性识别的电喷雾质谱研究

利用电喷雾质谱研究了β-环糊精、七-(2,6-二-O-甲基)-β-环糊精作为手性识别试剂对1,1'-联萘酚对映体的手性识别效应. 实验结果表明, 在气相中, β-环糊精与七-(2,6-二-O-甲基)-β-环糊精都可以与联萘酚形成非共价复合物. 对形成的复合物的串联质谱研究表明, β-环糊精不能识别联萘酚对映体, 而七-(2,6-二-O-甲基)-β-环糊精对联萘酚对映体有较强的手性识别效应. 进一步研究表明七-(2,6-二-O-甲基)-β-环糊精与联萘酚对映体混合比例以及CID能量对于手性识别并无影响.

Investigation of Chiral Recognition of 1 ,1'-Bi-2-naphthol Enantiomers by Heptakis-(2,6-di-O-methyl)-β-cyclodextrin with Electrospray Mass Spectrometry

Chiral recognition of enantiomeric 1,1'-bi-2-naphthol enantiomers by β- and heptakis-(2,6-di-O- methyl)-β-cyclodextrins as chiral selectors was investigated by electros-pray mass spectrometry. Comparative research shows that both β-cyclodextrin and hep-takis-(2,6-di-O-methyl)-β-cyclodextrin can form noncovalent complexes with 1,1'-bi-2-naphthol in gas phase. Investigation of tandem mass spectrometric data displays that β-cyclodextrin has little chiral recognition ability to the enantiomers but heptakis-(2,6-di-O- methyl)-β-cyclodextrin has strong chiral recognition ability. Our work also displays that mixing ratio of heptakis-(2,6-di-O-methyl)-β-cyclodextrin to 1,1'-bi-2-naphthol and the collision induced disossiation energy have no effect on chiral recognition.