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| 乌头与贝母配伍化学成分变化的UPLC/Q-TOFMS研究 | |
| 引用本文： | 王超,王宇光,梁乾德,让蔚清,肖成荣,高月.乌头与贝母配伍化学成分变化的UPLC/Q-TOFMS研究[J].化学学报,2011,69(16):1920-1928. |
| 作者姓名： | 王超 王宇光 梁乾德 让蔚清 肖成荣 高月 |
| 作者单位： | 1. 南华大学生命科学研究中心环境医学与放射卫生研究所,衡阳421001／军事医学科学院放射与辐射医学研究所药理与毒理研究室,北京100850 2. 军事医学科学院放射与辐射医学研究所药理与毒理研究室,北京,100850 3. 南华大学生命科学研究中心环境医学与放射卫生研究所,衡阳,421001 |
| 基金项目： | 国家重点基础研究发展计划(“973计划”)(No.2011CB505304); 北京市自然科学基金(No.7112110)资助项目 |
| 摘 要： | 利用UPLC/Q-TOFMS对中药十八反药对——乌头贝母配伍的合煎液与合并液进行检测,经过MassLynx 4.1分析其化学成分存在差异,发现合煎后次乌头碱水解受到部分抑制,而其他主要的双酯型二萜生物碱溶出较少且水解较彻底,乌头与川贝配伍合煎的毒性相对较小,因而可能通过合理炮制减毒后应用于临床治疗. |
| 关 键 词： | 十八反 UPLC Q-TOFMS 液质联用 乌头 贝母 |
Analysis of Chemical Composition in Combination of Aconitum and Fritillaria by UPLC/Q-TOFMS with Multivariate Statistical Analysis |
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| Wang,Chaoa,b Wang,Yuguang,b Liang,Qi,eb Rang,Weiqinga Xiao,Chengrongb Gao,Yue,b.Analysis of Chemical Composition in Combination of Aconitum and Fritillaria by UPLC/Q-TOFMS with Multivariate Statistical Analysis[J].Acta Chimica Sinica,2011,69(16):1920-1928. | |
| Authors: | Wang Chaoa b Wang Yuguang b Liang Qi eb Rang Weiqinga Xiao Chengrongb Gao Yue b |
| Institution: | Wang,Chaoa,b Wang,Yuguang,b Liang,Qiandeb Rang,Weiqinga Xiao,Chengrongb Gao,Yue,b(a Institute of Environmental Medicine and Radiation Hygiene,Research Center of Life Science,University of South China,Hengyang 421001)(b Institute of Radiation and Irradiation Medicine,Academy of Military Medical Sciences,Beijing 100850) |
| Abstract: | An ultra performance liquid chromatography coupled with time-of-flight mass spectrometry(UPLC/Q-TOFMS) based chemical profiling approach to evaluate chemical constitution between mixed decoction and co-decoction of Radix aconiti-Fritillaria combination of the Eighteen Incompatible Medications(Shi Ba Fan) was proposed.Two different kinds of decoctions,namely Radix aconiti-Fritillaria co-decoction: water extract of mixed two herbs,and Radix aconiti-Fritillaria mixed decoction: mixed water extract of each indi... |
| Keywords: | eighteen incompatible medications UPLC Q-TOFMS LC-MS Aconitum Fritillaria |
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