| 吡啶高三蝶烯的合成 |
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| 引用本文： | 张红,刘文杰,曹德榕,江焕峰.吡啶高三蝶烯的合成[J].化学学报,2011,69(17):2070-2074. |
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| 作者姓名： | 张红 刘文杰 曹德榕 江焕峰 |
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| 作者单位： | 1. 华南理工大学化学化工学院,广州510640／广东药学院医药化工学院,广州510006
2. 华南理工大学化学化工学院,广州,510640 |
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| 基金项目： | 国家自然科学基金(Nos.20872038,21072064); 高等学校博士学科点专项科研基金(No.20060561024)资助项目 |
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| 摘 要： | 2-溴-4-甲基吡啶（1）经氯代和碘代反应合成了2-溴-4-碘甲基吡啶（3）,3和蒽酮（4）反应生成10,10-二（2-溴-4-吡啶甲基）-9（10H）蒽酮（5）,5在3 MPa下与NaOCH3反应得到10,10-二（2-甲氧基-4-吡啶甲基）-9（10H）蒽酮（6）,6经硼氢化钠还原得到蒽醇（7）,7在对甲苯磺酸催化...
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| 关 键 词： | 高三蝶烯 吡啶高三蝶烯 10 10-二(2-甲氧基-4-吡啶甲基)-9(10H)蒽酮 蒽醇 1 7-亲电脱水反应 |
Synthesis of Pyridinylhomotriptycene |
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| Zhang,Honga,b Liu,Wenjiea Cao,Derong,a Jiang,Huanfenga.Synthesis of Pyridinylhomotriptycene[J].Acta Chimica Sinica,2011,69(17):2070-2074. |
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| Authors: | Zhang Honga b Liu Wenjiea Cao Derong a Jiang Huanfenga |
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| Institution: | Zhang,Honga,b Liu,Wenjiea Cao,Derong,a Jiang,Huanfenga(a School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640)(b School of Chemistry and Chemical Engineering,Guangdong Pharmaceutical University,Guangzhou 510006) |
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| Abstract: | 2-Bromo-4-methylpyridine(1) was converted to 2-bromo-4-iodomethylpyridine(3) by chlorina-tion and iodination;3 reacted with anthrone(4) to form 10,10-bis(2-bromopyridin-4-yl-methyl)-9(10H)anthrone(5).Methoxy group was introduced to pyridine ring by nucleophilic substitution at 3 MPa with NaOCH3 to give 10,10-bis(2-methoxypyridin-4-yl-methyl)-9(10H)-anthrone(6).6 was reduced by NaBH4 to give anthracenol(7).7 was catalyzed by p-TsOH to give pyridinylhomotriptycene(8) by an intramolecular 1,7-electrophilic deh... |
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| Keywords: | homotriptycene pyridinylhomotriptycene 10 10-bis(2-methoxypyridin-4-yl-methyl)-9(10H)anthrone anthracenol 1 7-electrophilic dehydration |
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