| 一个嫁接有羧酸羟基乙基酯的二吡啶吩嗪Ru(II)配合物的合成、与DNA的相互作用以及溶剂变色性质的研究 |
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| 引用本文： | 韩洋,杨维春,王科志.一个嫁接有羧酸羟基乙基酯的二吡啶吩嗪Ru(II)配合物的合成、与DNA的相互作用以及溶剂变色性质的研究[J].化学学报,2007,65(21):2382-2386. |
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| 作者姓名： | 韩洋 杨维春 王科志 |
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| 作者单位： | (1北京师范大学化学学院 北京 100875)
(2平顶山学院化学化工学院 平顶山 467002) |
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| 基金项目： | 国家自然科学基金
,
北京市自然科学基金
,
教育部高等学校博士学科点专项科研基金 |
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| 摘 要： | 合成并表征了一个新的Ru(II)配合物Ru(bpy)2(hedppc)](ClO4)2 {bpy＝2,2'-联吡啶, hedppc＝二联吡啶3,2-a: 2',3'-c]吩嗪-11-羧酸(2-羟乙基)酯}. 通过紫外-可见吸收光谱、与溴化乙锭竞争实验、粘度测量和DNA裂解实验研究了配合物与小牛胸腺DNA的相互作用性质. 结果表明配合物以插入模式与DNA键合，键合常数Kb＝(6.99±1.34)×106 mol－1•L (s＝2.03±0.04)与母体配合物Ru(bpy)2 (dppz)]2＋相近，但光致发光和溶剂变色等光学性质与Ru(bpy)2 (dppz)]2＋有明显的差别.
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| 关 键 词： | 钌(II) DNA 紫外-可见吸收光谱 溶剂变色 |
| 收稿时间： | 2007-04-14 |
| 修稿时间： | 2007-04-14 |
Study on the Synthesis, DNA Interaction, and Solvatochromism of a Hydroxyethyl Carboxylate-Grafted Dipyridophenazine Ruthenium(II) Complex |
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| HAN Yang,YANG Wei-Chun,WANG Ke-Zhi.Study on the Synthesis, DNA Interaction, and Solvatochromism of a Hydroxyethyl Carboxylate-Grafted Dipyridophenazine Ruthenium(II) Complex[J].Acta Chimica Sinica,2007,65(21):2382-2386. |
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| Authors: | HAN Yang YANG Wei-Chun WANG Ke-Zhi |
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| Institution: | (1 College of Chemistry, Beijing Normal University, Beijing 100875)
(2 College of Chemistry and Chemical Engineering, Pingdingshan Univer-sity, Pingdingshan 467002) |
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| Abstract: | A new ruthenium(II) polypyridyl complex of Ru(bpy)2(hedppc)](ClO4)2 {in which bpy＝2,2'-biyridine, hedppc＝2-hydroxyethyl dipyrido3,2-a:2',3'-c]phenazine-11-carboxylate} was synthesized and characterized by elemental analysis, 1H NMR and MALDI-TOF MS. The binding of the com-plex to calf thymus (ct) DNA was studied with UV-visible absorption and luminescence spectrophotometric titrations, DNA competitive binding with ethidium bromide, viscosity measurements and thermal denatura-tion experiments. The results indicated that the complex was bound to ct-DNA through an intercala-tive mode with an intrinsic binding constant of (6.99±1.34)×106 L/mol in buffered 50 mmol/L NaCl comparable to parent Ru(bpy)2(dppz)]2＋. The complex is per-manently non-emissive in the absence and presence of the DNA, and exhibits intriguing solvatochromic properties different from parent Ru(bpy)2(dppz)]2＋. |
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| Keywords: | ruthenium(II) DNA UV-vis absorption spectroscopy solvatochromism |
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