| 穿心莲中两个黄酮苷的波谱学研究 |
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| 引用本文： | 任秀华,杜光,周冰峰,宗凯,马宝瑕.穿心莲中两个黄酮苷的波谱学研究[J].化学学报,2007,65(14):1399-1402. |
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| 作者姓名： | 任秀华 杜光 周冰峰 宗凯 马宝瑕 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院药学部,武汉,430030
2. 浙江京新药业股份有限公司,新昌,310000 |
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| 摘 要： | 研究了穿心莲中抗血栓的活性成分. 应用AB-8大孔吸附树脂、聚酰胺柱色谱及薄层色谱进行分离, 应用波谱学(1H NMR, 13C NMR, DQFCOSY, TOCSY, HMQC, HMBC, NOESY等)方法进行结构鉴定. 分离得到两个黄酮苷类化合物, 确定了1H NMR, 13C NMR信号的全归属. 化合物1鉴定为5,4'-二羟基-7-甲氧基黄酮-6-O-β-D-葡萄糖苷, 化合物2鉴定为5,4'-二羟基-7-甲氧基黄酮-8-O-β-D-葡萄糖苷, 化合物1为首次从该植物中分得, 首次对两个化合物的碳谱和氢谱进行了全归属.
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| 关 键 词： | 穿心莲 5 4'-二羟基-7-甲氧基黄酮-6-O-β-D-葡萄糖苷 5 4'-二羟基-7-甲氧基黄酮-8-O-β-D-葡萄糖苷 核磁共振 结构分析 |
| 收稿时间： | 2006-11-1 |
| 修稿时间： | 2006-11-012007-03-28 |
Study on the Spectroscopy of Two Flavonyl Glycosides from Andrographis paniculata |
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| REN Xiu-Hua,DU Guang,ZHOU Bing-Feng,ZONG Kai,MA Bao-Xia.Study on the Spectroscopy of Two Flavonyl Glycosides from Andrographis paniculata[J].Acta Chimica Sinica,2007,65(14):1399-1402. |
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| Authors: | REN Xiu-Hua DU Guang ZHOU Bing-Feng ZONG Kai MA Bao-Xia |
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| Institution: | (Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030)(Zhejiang Jingxin Pharmaceutical Co., Ltd., Xinchang 310000) |
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| Abstract: | To study the bioactive constituents from Andrographis paniculata, two compounds were isolated and purified by column chromatography on AB-8 macroporous adsorption resin and polyamide. The structures were determined by various spectroscopic data, including UV, FABMS, 1H NMR, 13C NMR, DQFCOSY, TOCSY, HMQC, HMBC and NOESY. The 1H NMR and 13C NMR signals of these two compounds were assigned. The structures of these two compounds were elucidated as 5,4'-dihydroxy-7-methoxyflavon-6-yl-β-D-pyranoglucoside and 5,4'-dihydroxy-7-methoxyflavon-8-yl-β-D-pyranoglucoside, res- pectively. |
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| Keywords: | Andrographis paniculata 5 4'-dihydroxy-7-methoxyflavon-6-yl-β-D-pyranoglucoside 5 4'-dihydroxy-7-methoxyflavon-8-yl-β-D-pyranoglucoside NMR structure analysis |
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