含有金刚烷胺的多金属氧酸盐的合成和抗流感病毒活性

以金刚烷胺和1∶10 (Ln∶W), 1∶13(Ni或Mn∶V)系列多金属氧酸盐为原料, 合成了化学式分别为K₄(C₁₀H₁₈N)₅CeW₁₀O₃₆•2H₂O (APOM-5), K₄(C₁₀H₁₈N)₅PrW₁₀O₃₆•2H₂O (APOM-6), K₃(C₁₀H₁₈N)₄NiV₁₃O₃₈•H₂O (APOM-12)和K₃(C₁₀H₁₈N)₄MnV₁₃O₃₈•H₂O (APOM-13)的四种新的多金属氧酸盐, 并通过元素分析、IR光谱及¹H NMR谱对其结构进行了表征. 在狗肾(Madin-Darby canine kidney, MDCK)细胞内, 对合成化合物进行了抗流感病毒A和B的活性研究. 发现APOM-13对流感病毒A, B两型均有明显的抑制活性, 而APOM-12只在浓度较高时对流感病毒A, B两型有抑制活性, 低浓度时, 活性不明显. APOM-5,6对A型流感病毒有效, 但对B型流感病毒抑制活性不明显. 另外发现APOM-12和APOM-13对流感病毒感染MDCK细胞病变效应(CPE)具有明显抑制作用, 且浓度越大抑制作用愈明显.

Synthesis and Anti-influenza Virus Activity of Polyoxometalates Containing Amantadine

Four novel polyoxometalates constructed from amantadine and a series of polyoxometalates 1∶10 (Ln∶W) and 1∶13 (Ni or Mn∶V)], which can be formulated as K₄(C₁₀H₁₈N)₅CeW₁₀O₃₆•2H₂O (APOM-5), K₄(C₁₀H₁₈N)₅PrW₁₀O₃₆•2H₂O (APOM-6), K₃(C₁₀H₁₈N)₄NiV₁₃O₃₈•H₂O (APOM-12) and K₃(C₁₀H₁₈N)₄MnV₁₃O₃₈•H₂O (APOM-13) respectively, have been synthesized and characterized by elemental analysis, IR and ¹H NMR spectroscopy methods. The antivirus activity of the synthesized compounds was investigated on the inhibitory effect against both influenza types A and B in Madin-Darby canine kidney (MDCK). It indicates that APOM-13 had significant inhibitory activity against both A and B and APOM-12 had inhibitory activity against both A and B only in high concentration but it was not remarkable in low concentration. APOM-5 and APOM-6 have effectively activity against influenza A but not significantly towards B. In addition, it was found that APOM-12 and APOM-13 exhibited good inhibitory effect on MDCK cytopathogenic effect (CPE) that was infected with influenza virus and the inhibitory activity was more evident in higher concentration.