海枫藤中C21甾体苷的分离和结构测定

从萝摩科植物海枫藤Marsdenia officinalis Tsiang et P.T.Li.]的藤茎中分离得到四个C21甾体去氧糖苷(1)～(4). 通过化学降解和波谱技术, 确定它们的化学结构依次为: 12-O-桂皮酰基-20-O-乙酰基(20S)-孕甾烷-6-烯-3β,5α,8β,12β,14β, 17β,20-庚醇 3-O-甲基-6-去氧-β-D-阿洛吡喃糖基-(1→4)-β-D-夹竹桃吡喃糖基-(1→4)-β-D-磁麻吡喃糖苷(1), 12-O-桂皮酰基-20-O-乙酰基(20S)-孕甾烷-6-烯-3β,5α,8β,12β,14β,17β,20-庚醇3-O-β-D-葡萄吡喃糖基-(1→4)-3-O-甲基-6-去氧-β-D-阿洛吡喃糖基-(1→4)-β-D-磁麻吡喃糖基-(1→4)-β-D-磁麻吡喃糖苷(2), 12-O-桂皮酰基-20-O-乙酰基(20S)-孕甾烷-6- 烯-3β,5α,8β,12β,14β,17β,20-庚醇3-O-β-D-黄夹吡喃糖基-(1→4)-β-D-磁麻吡喃糖基-(1→4)-β-D-磁麻吡喃糖苷(3), 12-O-烟酰基-肉珊瑚苷元3-O-β-D-葡萄吡喃糖基-(1→4)-3-O-甲基-6-去氧-β-D-阿洛吡喃糖基-(1→4)-β-D-夹竹桃吡喃糖基- (1→4)-β-D-磁麻吡喃糖基-(1→4)-β-D-磁麻吡喃糖苷(4). 其中1和2为新化合物, 分别命名为haifengtenoside A, haifengtenoside B, 3和4分别为已知化合物mucronatoside H 和 hainaneosides A, 系首次从该植物中分离得到.

Isolation and Structure Determination of Steroidal Glycosides from the Stems of Marsdenia officinalis Tsiang et P.T.Li.(Asclepiadaceae)

Two new polyoxypregnane glycosides, haifengtenoside A (1) and haifengtenoside B (2), together with two known mucronatoside H (3) and hainaneosides A (4) were obtained from the stems of Marsdenia officinalis Tsiang et P.T.Li. (Asclepiadaceae). Their structures were elucidated as 12-O-cinnamoyl-20-O- acetyl(20S)-pregn-6-ene-3β,5α,8β,12β,14β,17β,20-heptanol 3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)- β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranoside (1); 12-O-cinnamoyl-20-O-acetyl(20S)-pregn-6-ene-3β, 5α,8β,12β,14β,17β,20-heptanol 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl- (1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside(2); 12-O-cinnamoyl-20-O-acetyl(20S)-pregn- 6-ene-3β,5α,8β,12β,14β,17β,20-heptanol 3-O-β-D-thevetopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β- D-cymaropyranoside(3); 12-O-nicotinoylsarcostin 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D- allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (4), respectively, on the basis of spectroscopic and chemical means.