糖类研究LIV.肝癌相关糖抗原SM_3寡糖链的合成研究

SM_3是寡糖链中带有硫酸酯基的酸性鞘糖脂，在正常人肝中含量极少，而在培 养的人肝细胞癌细胞系和人肝癌细胞手术标本中均有明显堆积。因此，SM_3可望作 为人肝细胞癌的肿瘤相关糖抗原，建立机体的特异性主动免疫。本文经过11步反应 ，首次合成了带连接臂的SM_3寡糖链，为今后合成具有更高分子量的糖基缀合物并 研究其抗肿瘤免疫原性奠定了基础。

Studies on Carbohydrates LIV. Studies on the Synthesis of an Analogue of SM_3, a Cancer Associated Carbohydrate Antigen of HCC

SM 3 is a sulfated glycolipid, in which the neutral sugar chain is modified by sulfate residue.The amount of sulfated glycolipids in normal liver cell is very small, however, highly expression of SM 3 is found in human heptacellular carcinoma(HCC) cells and tissues. Therefore, it is suggested that SM 3 may be the important cancer associated carbohydrate antigen of HCC. In this paper, one spacer armed analogue of a disaccharide SM 3 was synthesized for the first time via multi step synthetic method. The target compound is suitable for conjugation to a carrier by the presence of a 2 amino ethyl spacer, and therefore is useful for application in immunological study later.