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| 磷脂水解与胆固醇型胆结石时的可能生成机理 | |
| 引用本文： | 徐怡庄,杨展澜,翁诗甫,刘虎威,李维红,张煦,吴瑾光,徐端夫,Somjen G.磷脂水解与胆固醇型胆结石时的可能生成机理[J].化学学报,2002,60(4):711-714. |
| 作者姓名： | 徐怡庄 杨展澜 翁诗甫 刘虎威 李维红 张煦 吴瑾光 徐端夫 Somjen G |
| 作者单位： | 1. 北京大学化学系稀土材料化学及应用国家重点实验室,北京,100871;中国科学院化学研究所高分子化学和物理国家重点实验室,北京,100080 2. 北京大学化学系稀土材料化学及应用国家重点实验室,北京,100871 3. 中国科学院化学研究所高分子化学和物理国家重点实验室,北京,100080 |
| 基金项目： | 国家重点基础研究发展规划项目 (No .G19980 6 130 7)，国家自然科学基金 (Nos .2 990 10 0 2 ,2 96 710 0 2 ,39730 16 0 ,2 0 0 2 30 0 5 ,5 97330 6 0, 5 98730 30 ,5 995 30 0 1,5 990 30 0 8)，中国科学院知识创新工程 (No .KJCX1 Y 0 3)，稀土材料化学国家重点实 |
| 摘 要： | 用胆酸盐-磷脂-胆固醇-水体系模拟胆汗的化学行为。在体系中发现，磷脂可 以发生降解形成脂肪酸。而在胆汗中，磷脂在增溶固醇的过程中起到了十分重要的 作用。依此，我们提出磷脂的水解可能与胆固醇型胆结石的生成有密切关系。 |
| 关 键 词： | 胆酸 磷脂 胆固醇 红外分光光度法 |
| 修稿时间： | 2001年8月24日 |
Hydrolysis of Phospholipid and Possible Mechanism of Gallstone Formation |
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| Somjen G.Hydrolysis of Phospholipid and Possible Mechanism of Gallstone Formation[J].Acta Chimica Sinica,2002,60(4):711-714. | |
| Authors: | Somjen G |
| Institution: | State Key Laboratory of Rare Earth Material Chemistry and Applications, Department of Chemistry, Peking University.Beijing (100871);State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences.Beijing(100080) |
| Abstract: | Taurocholic salt-phospholipid-cholesterol-water solubilized systems were used to investigate the physical/chemical behavior of bile. Phase separation that produces float and precipitation was observed in the system. Analysis using FT-IR spectroscopy and GC-MS methods showed that aliphatic acids were principal component of the float. This demonstrated that hydrolysis of phospholipid must have occurred in the system. Considering that phospholipid plays a very important role in solubilizing cholesterol in bile, whereas aliphatic acids can not solubilize cholesterol, we suggest that the hydrolysis of phospholipid may be related to the formation of gallstone. |
| Keywords: | FT-IR phospholipid cholesterol gallstone |
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