| 聚乳酸/壳聚糖纳米纤维结构形成的影响条件及其生物矿化活性 |
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| 引用本文： | 刘淑琼,吴芳芳,吴方棣,吕志玉.聚乳酸/壳聚糖纳米纤维结构形成的影响条件及其生物矿化活性[J].高分子通报,2020(3):33-39. |
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| 作者姓名： | 刘淑琼 吴芳芳 吴方棣 吕志玉 |
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| 作者单位： | 武夷学院生态与资源工程学院福建省生态产业绿色技术重点实验室 |
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| 基金项目： | 福建省生态产业绿色技术重点实验室开放课题(WYKF2018-12);福建省大学生创新创业训练项目(201810397037,201910397034)。 |
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| 摘 要： | 以二氧六环/冰醋酸为溶剂体系,采用相分离法制备了聚乳酸(PLA)/壳聚糖(CS)复合纳米纤维结构的组织工程支架,探讨了不同CS含量、不同凝胶温度及不同分子量对PLA/CS复合支架纳米纤维结构的影响以及支架的生物活性。结果表明,凝胶温度对PLA/CS复合材料的纳米纤维结构影响较大,且随着温度的降低,结构的微观尺寸也逐渐增大,从纳米级上升到普通的尺寸结构;CS含量对PLA/CS复合支架的基体结构影响不大;实验范围内PLA分子量对PLA/CS复合支架的纳米纤维结构有重要影响:分子量大的样品,较易得到PLA/CS复合纳米纤维结构的材料,而分子量小的样品则不能得到纳米纤维结构。另外,生物矿化实验表明CS的添加有利于PLA/CS复合材料生物活性的提高。
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| 关 键 词： | 聚乳酸 壳聚糖 纳米纤维 生物活性 |
The Effects Condition on the Nanofibrous Structures of Poly(lactic acid)/Chitosan Scaffolds and Bio-mineralization Activity |
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| Institution: | (Fujian Provincial Key laboratory of Eco-Industrial Green Technology,College of Ecological and Resources Engineering,Wuyi University,Wuyishan 354300,China) |
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| Abstract: | Poly(lactic acid)(PLA)/chitosan(CS)composite nanofibrous scaffolds were fabricated from a quaternary PLA/CS/dioxane/glacial acetic acid system by phase separation method.The effects of gelation temperature,CS content and the molecular weight of PLA on the morphology of composite scaffolds were investigated.The results revealed that gelation temperature and the molecular weight of PLA significantly influenced the formation of nanofibrous structure,but the CS content had very litter effect on the nanofibrous structure.The microstructure of the PLA/CS composite scaffolds changed greatly with the reduction of gelation temperature,from nano-structure to micro-structure.Besides,high molecular weight of PLA make for nanofibrous structure easier than the low molecular weight of PLA in this work.The mineralization results showed that PLA/CS composite nanofibrous scaffolds could induce hydroxyapatite formation faster than pure PLA nanofibrous scaffolds. |
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| Keywords: | Poly(lactic acid) Chitosan Nanofibrous Bioactivity |
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