化学修饰壳聚糖的血液相容性

壳聚糖是无毒、可生物降解、具有生物相容性的天然碱性多糖。本文综述了近年来提高壳聚糖的血液相容性的方法及以壳聚糖为原料制备肝素替代品的研究。壳聚糖分子上接枝血液相容性高分子、引入亲水基团或负电基团、酰化改性等均能提高壳聚糖的血液相容性;以壳聚糖为原料制备肝素的替代品可通过在壳聚糖分子上引入磺酸基,或将壳聚糖氧化成6-羧基壳聚糖后再引入磺酸基来实现。对今后如何进一步提高壳聚糖衍生物的血液相容性研究前景进行了展望。

Review on the Blood Compatibility of Chemical Modification Chitosan

Chitosan,a nature aminopolyose,was of nontoxic,biodegradable,and biocompatible.Both the methods of modifying the blood compatibility of chitosan and the methods of preparing substitute for heparin from chitosan were reviewed in this article.Cross-linking blood compatible polymer,such as heparin,inducing hydrophilic groups,negatively charged groups,or acyl groups onto chitosan molecule could develop the blood compatibility of chitosan.The substitute for heparin could obtain by grating sulfo groups to chitosan or 6-carboxychitosan,the production of chitosan selective oxidization.The general view of the research trends of increasing the blood compatibility of chemical modification chitosan were given,too.