| PNIPA类纳米水凝胶在药物缓控释研究中的应用 |
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| 引用本文： | 张建,陈海燕,顾月清.PNIPA类纳米水凝胶在药物缓控释研究中的应用[J].高分子通报,2007(10):52-56. |
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| 作者姓名： | 张建 陈海燕 顾月清 |
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| 作者单位： | 中国药科大学生命科学与技术学院,南京,210038 |
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| 基金项目： | 国家自然基金(30371362,30672015) |
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| 摘 要： | 简要介绍了聚N-异丙基丙烯酰胺(Poly N-isopropylacrylamide, PNIPA)类纳米水凝胶的性质及智能响应机理,并重点综述了近年来此类纳米水凝胶在药物缓控释研究中的应用:作为脂溶性小分子药物的载体,达到增溶及缓控释药物的效果,并增强药物的稳定性及生物活性;作为水溶性小分子药物的载体,达到缓释该类药物的效果;作为生物大分子药物(蛋白,多糖)的载体,克服直接用药时的弊端;此外,还可作为基因工程载体.
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| 关 键 词： | PNIPA 纳米水凝胶 温敏性 缓释 控释 |
Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release |
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| ZHANG Jian,CHEN Hai-yan,GU Yue-qing.Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release[J].Polymer Bulletin,2007(10):52-56. |
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| Authors: | ZHANG Jian CHEN Hai-yan GU Yue-qing |
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| Institution: | School of Life Science and Technology, China Pharmaceutical University, Nanjing 210038, Ch/na |
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| Abstract: | In this article,the properties and the responsive mechanism of PNIPA nano-hydrogels were briefly introduced.And then more emphasis was placed on the application of PNIPA nano-hydrogels as drug carriers for controlled and sustained drug release.They provide liposoluble drugs with stability,solubility,bioactivity.And hydrosoluble drugs entrapped in PNIPA nano-hydrogels can be sustainedly released.They can also be used as carriers for biomacromolecule drugs to avoid disadvantage in application.PNIPA nano-hydrogels are also favourable gene engineering carriers. |
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| Keywords: | PNIPA Nano-hydrogel Thermosensitive Sustained release Controlled release |
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