| 可生物降解的药物缓释膜片研究进展 |
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| 引用本文： | 马春宝,康春生,原续波,常津.可生物降解的药物缓释膜片研究进展[J].高分子通报,2005(6):65-69,75. |
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| 作者姓名： | 马春宝 康春生 原续波 常津 |
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| 作者单位： | 天津大学材料学院纳米生物技术研究所,天津,300072;天津大学材料学院纳米生物技术研究所,天津,300072;天津大学材料学院纳米生物技术研究所,天津,300072;天津大学材料学院纳米生物技术研究所,天津,300072 |
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| 基金项目： | 国家自然科学基金（50373033）;天津市自然科学重点基金（05YFJZJC01001）; |
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| 摘 要： | 利用生物降解高分子材料物理包埋或化学结合需要缓释的药物制成植入膜片，药物从聚合物的孔道中扩散出来，以一定的速率释放，从而达到局部缓释、控释的目的。本文从聚合物材料、制备方法和释放机理等方面综述了近年来国内外生物降解药物缓释膜片的进展情况。
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| 关 键 词： | 生物降解 缓释 膜片 |
The Development of Biodegradable Drug Release Implants in Vivo |
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| MA Chun-bao,KANG Chun-sheng,YUAN Xu-bo,CHANG Jin.The Development of Biodegradable Drug Release Implants in Vivo[J].Polymer Bulletin,2005(6):65-69,75. |
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| Authors: | MA Chun-bao KANG Chun-sheng YUAN Xu-bo CHANG Jin |
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| Institution: | Institute of Nanobiotechnology, School of Material Science and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | The implants were prepared by biodegradable polymers and drugs with physical packing or chemical connection ways. The drug in the polymer can diffuse from the channel of polymer with constant speed. It can affect only in the local site rather than in systemic tissues. The development of polymer matrix, preparation method, release mechanism of drug for biodegradable implants were also reviewed. |
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| Keywords: | Biodegradation Sustained release Implant |
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