小剂量SmCl3对大鼠甲状腺结构和功能的影响

应用放射免疫测定研究了大白鼠经腹腔注射，灌胃和静脉注射小剂量ＳｍＣｌ３，０．０５ｍｇ／ｋｇ后，血清中甲状腺激素和促甲状腺激素浓度的变化；并在电镜观察了甲状腺和腺垂体促甲状腺激素细胞的超微结构。

Effects of Low Concentration Samarium Chloride on the Ultrastructure and Functions of Rat Thyroid Gland

he levels of thyroxine(T3, T4 ) and thyroid stimulating hormone (TSH) in rat serum were measured by radioimmunoassay , and also ultrastructures of the thyroid gland and adenohypophyseal thyrotroph were examined by transmission electronic microscope (TEM), after the rats were given low concentration(0. 05 mg/kg) of samarium chloride by the intraperitoneal, oral and tail intravenous. The results showed that the level of T4 in the rat serum increased and the level of TSH unchanged abviously by the intraperitoneal, and the levels of T3, T4 and TSH were not increased significantly by oral and tail intravenous. The evidences mentioned above were accord with the morphological changes of thyroid follicular epithelial cell and adenohypophysis thyrotroph seen under electronic microscopy in a sense.