| 侧脑室注射氯化镧对大鼠血清生长素和甲状腺素的影响 |
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| 引用本文： | 祝世功.侧脑室注射氯化镧对大鼠血清生长素和甲状腺素的影响[J].中国稀土学报,1999,17(2):153-156. |
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| 作者姓名： | 祝世功 |
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| 作者单位： | 白求恩医科大学基础医学院 |
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| 摘 要： | 西方研究了侧脑室注入ＬａＣｌ３对大鼠血清中生长系，甲状腺素，促甲状腺素和下丘脑中生长抑素的影响。侧脑室注射０．００１和０．０１ｍｏｌ．ｌ＾－１ＬａＣｌ３，血清中Ｔ４和ＧＨ含量明显高于对照组，０．１和０．５ｍｏｌ．ｌ＾－１ＬａＣｌ３组血清Ｔ４和ＧＨ未见明显变化。
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| 关 键 词： | 稀土 氯化镧 生长素 甲状腺素 大鼠 神经内分泌 |
| 修稿时间： | 19981105 |
Effects of LaCl3 on GH and Thyroxin in Rat Serum afterInjected into Cerebral Lateral Ventricle |
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| Zhu Shigong,Wang Jianchun,Li Tianshu,Wang Shao,Nie Yuxiu.Effects of LaCl3 on GH and Thyroxin in Rat Serum afterInjected into Cerebral Lateral Ventricle[J].Journal of the Chinese Rare Earth Society,1999,17(2):153-156. |
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| Authors: | Zhu Shigong Wang Jianchun Li Tianshu Wang Shao Nie Yuxiu |
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| Abstract: | he
effects of LaCl3 on growth hormone(GH), thyroxin(T3, T4), thyrotrophin(TSH) in serum and
somatostatin(SS) in hypothalamus were studied after LaCl3 was injected into cerebral lateral
ventricle of rat. The results show that the contents of GH, T4 in serum are higher than that of
saline control(P<005, P<001) after single injection with 0001 and 001 molL-1 LaCl3. However,
the 01 and 05 molL-1 of LaCl3 does not show effect on the hormones. In multiple injection
experiment, 01 molL-1 of LaCl3 elevates the contents of GH, TSH, T3 and T4 in serum(P<005).
The content of somatostatin(SS) in hypothalamus of rats with obvious changes of serum
hormone is lower than that of control rats. The results indicate that certain amount of LaCl3 in
cerebral lateral ventricle induces the secretion of growth hormone and thyroxin, and the effect
mechanism may be related to the decrease of SS in hypothalamus and increase of TSH in
adenohypohysis. |
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| Keywords: | Rare earths LaCl3 Growth hormone Thyroxin Rat |
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