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Asymmetric synthesis XXVII: Asymmetric catalytic trimethylsilylcyanation of aldehydes by novel Ti-chiral Schiff base complexes |
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| Authors: | Jiang Yaozhong Zhou Xiangge Hu Wenhao Li Zhi and Mi Aiqiao |
| Institution: | Chengdu Institute of Organic Chemistry, Academia Sinica, 610041, P.R.China |
| Abstract: | Enantioselective catalytic trimethylsilylcyanations of aldehydes with 48% to 92% e.e. have been studied using the novel Ti-chiral Schiff base complexes. We have found that the catalyst led to high enantoselectivity when the molar ratio of the Schiff base 1 to Ti(O-i-Pr)4 was 2:1. |
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