The pH of the reaction controls the stereoselectivity of organocatalyzed direct aldol reactions in water |
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| Authors: | Swapandeep Singh Chimni Sarbjit Singh Akshay Kumar |
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| Institution: | aDepartment of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India |
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| Abstract: | The direct aldol reaction of 4-nitrobenzaldehyde and cyclohexanone, catalyzed by a protonated prolinamide catalyst in water, proceeds with the formation of aldol product that has high diastereoselectivity and enantioselectivity in an optimal pH range of 4–5. |
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