A new set of orthogonal-protecting groups for oligosaccharide synthesis on a polymeric support |
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| Institution: | 1. Department of Pediatrics, Baylor College of Medicine and Section of Infectious Diseases, Texas Children''s Hospital, Houston, TX 77030, USA;1. M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation;2. Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, SE-221 84 Lund, Sweden;3. School of Engineering, Computer & Mathematical Sciences, Auckland University of Technology, 1010 Auckland, New Zealand;1. Department of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, MD 20742, United States;2. Complex Carbohydrate Research Center, University of Georgia, Athens 30602, Georgia;1. Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005, Paris, France;2. Drug Sciences Department, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy;3. Italy Centro Servizi Interdipartimentale – STA, University of Rome “Tor Vergata”, Rome, Italy;4. Department of Biology, University of Rome “Tor Vergata”, Rome, Italy;5. Department of Pharmaceutical Sciences, University of Milan, via Mangiagalli 25, 20133, Milan, Italy;6. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, China |
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| Abstract: | The hydroxyl-protecting groups, levulinoyl (Lev) and 9-fluorenylmethoxycarbonyl (Fmoc), and the amino-protecting group 2,2,2-trichloroethoxycarbonyl (Troc), offer an ideal set of orthogonal-protecting groups which are compatible with oligosaccharide synthesis on a methylpolyethyleneglycol (MPEG) support using a p-alkyloxybenzyl-type linker. |
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