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Asymmetric palladium(0)-mediated synthesis of 2-vinylchroman
Institution:1. Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;4. Universidade Federal de Viçosa, Viçosa, MG, Brazil;1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China;3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China;4. State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China
Abstract:Optically active 2-vinylchroman was synthesized from the corresponding hydroxy allylic carbonate by palladium-catalyzed cyclization in the presence of various chiral ligands. Enantioselectivity of up to 53% was obtained using NMDPP as the chiral phosphine.
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