Qualitative Discrimination Between Paracetamol Tablets Made by Near Infrared Spectroscopy and Chemometrics With Regard to Polymorphism |
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| Authors: | M Khanmohammadi A B Garmarudi N Moazzen K Ghasemi |
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| Institution: | (1) NIR Technologies Inc., 1312 Fairmeadow Trail, Oakville, ON, Canada, L6M 2M2;(2) Food Research Program, Agriculture and Agri-Food Canada, Guelph, ON, Canada;(3) Body Composition Laboratory and Weight Control Unit, St. Luke’s-Roosevelt Hospital Center, New York, NY 10025, USA;(4) Present address: Merck and Co., Inc., Clinical Research, Metabolism, Whitehouse Station, NJ, USA |
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| Abstract: | Polymorphism is an important characteristic of pharmaceutical products because different polymorphs exhibit different physicochemical
stabilities, dissolution rates, etc., which makes them different in therapeutic efficiency. Thus, it is important to control
the polymorphic structure of pharmaceutical products. A spectroscopy method based on Fourier transform near infrared (FT-NIR)
spectroscopy and chemometric techniques is introduced to classify paracetamol preparations according to polymorphic changes.
X-ray diffraction (XRD) and FT-NIR studies were carried out on standard samples, paracetamol preparations (acetaminophen tablet),
and also the additives. A direct comparison was performed between the spectroscopic data and those obtained by XRD. The NIR
and XRD analyses of paracetamol preparations show some distinct differences, particularly in the Iranian tablet. These differences
are found to be related to polymorphism and paracetamol purity. The cluster analysis (CA) and principal component analysis
(PCA) were utilized to classify the paracetamol preparations. FT-NIR spectroscopy provides a simple, rapid and accurate qualitative
analysis method for the identification of paracetamol polymorphs. |
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