A new 5-alkylresorcinol glucoside derivative from Cybianthus magnus |
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| Authors: | B Cabanillas P Vásquez-Ocmín I Zebiri E Rengifo M Sauvain HL Le |
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| Institution: | 1. Instituto de Investigaciones de la Amazonía Peruana (IIAP), Iquitos, Peru;2. Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru;3. Institut de Chimie Moléculaire de Reims UMR CNRS, Université, de Reims BP 1039, 51687, REIMS, Cedex, France;4. Laboratoire de Pharmacochimie et Pharmacologie pour le Développement, Pharma-DEV, Université de Toulouse, UPS, UMR 152, F-31062 Toulouse, Cedex 9, France;5. Institut de Recherche pour le Développement (IRD), UMR152, Mission IRD, Casilla 18-1209, Lima, Peru |
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| Abstract: | One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds, isolated from four plants belonging to Myrsinaceae family (2, 3 isolated from C. magnus; 4–7, 10 and 11 isolated from Myrsine latifolia; 4, 8 and 9 isolated from Myrsine sessiflora; 6, 7, 10, 12 and 13 isolated from Myrsine congesta). Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. So far, only nine 5-alkylresorcinol glucosides were isolated from leaves of Grevillea robusta. Since resorcinols are known to exhibit strong cytotoxic activity, compounds 1 and 2 were tested against cell lines 3T3, H460, DU145 and MCF-7 for cytotoxicity in vitro and compounds 3–13 were tested for their antileishmanial activity. Compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 μM for all tested cell lines. Compounds 3–13 were not active against Leishmania amazonensis amastigotes. |
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| Keywords: | alkylresorcinol secondary metabolites Myrsinaceae anti-leishmaniasis cytotoxicity |
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