Novel regulation of aflatoxin B1 biosynthesis in Aspergillus flavus by piperonal |
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| Authors: | Eun-Sil Park In Kyung Bae Ho Jin Kim |
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| Institution: | 1. School of Applied Sciences, Kyungpook National University, Daegu, Republic of Korea;2. National Agricultural Products Quality Management Service, Kimcheon, Republic of Korea |
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| Abstract: | The present study investigated its inhibitory role in aflatoxin (AF) biosynthesis. Treating only AFB1- and B2-producing Aspergillus flavus with piperonal completely inhibited AFB1 production with high sclerotial formation, resulting in 20-fold higher AFG2 production. On the other hand, benzodioxole and eugenol suppressed AFB1 production without AFG formation, while methyleugenol showed potent inhibition of AFB1 production with slight production of AFG1. These results indicate that natural products may change aflatoxin biosynthesis, and highlight a novel regulation of AFG2 production by piperonal. It is the first report for chemical regulation on AFG2 production in non-AFG producing-aspergilli. |
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| Keywords: | Piperonal Aspergillus flavus aflatoxin B1 biosynthesis aflatoxin G2 |
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