Bioactive compounds from the endophytic fungus Fusarium proliferatum |
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| Authors: | Zerihun T Dame Beauty Silima Marieka Gryzenhout |
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| Institution: | 1. Department of Organic and Biomolecular Chemistry, University of G?ttingen, Tammannstra?e 2, D-37077 G?ttingen, Germany;2. Department of Chemistry, University of Venda, P/Bag X5050, Thohoyandou 0950, South Africa;3. Department of Plant Sciences, University of the Free State, PO Box 339, Bloemfontein 9300, South Africa |
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| Abstract: | The crude extract of an endophytic fungus isolated from Syzygium cordatum and identified as Fusarium proliferatum showed 100% cytotoxicity against the brine shrimp Artemia salina at 100 μg/mL. Seven coloured, biologically active metabolites – including ergosta-5,7,22-trien-3β-ol, nectriafurone-8-methyl ether, 9-O-methyl fusarubin, bostrycoidin, bostrycoidin-9-methyl ether and 8-hydroxy-5,6-dimethoxy-2-methyl-3-(2-oxo-propyl)-1,4-naphthoquinone– were isolated from the extract. |
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| Keywords: | Endophytic fungus Syzygium cordatum Fusarium proliferatum naphthoquinone |
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