A new amino amidine derivative from the wood-decaying fungus Xylaria cf. cubensis SWUF08-86 |
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| Authors: | Sasiphimol Sawadsitang Nuttika Suwannasai Wiyada Mongkolthanaruk Peni Ahmadi |
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| Institution: | 1. Natural Products Research Unit, Faculty of Science, Department of Chemistry, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Khon Kaen University, Khon Kaen, Thailand;2. Faculty of Science, Department of Biology, Srinakharinwirot University, Bangkok, Thailand;3. Faculty of Science, Department of Microbiology, Khon Kaen University, Khon Kaen, Thailand;4. Faculty of Science, Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Okinawa, Japan |
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| Abstract: | The secondary metabolites of Xylaria cf. cubensis SWUF08-86 fungus were investigated, and the chromatographic separation of the crude extracts yielded seventeen compounds. The structure elucidation by spectroscopic analysis including 1D and 2D NMR and the comparison of these data with literature, along with HREIMS spectrometry, revealed one new amino amidine derivative (1), together with five known simple cyclic dipeptide analogs, diketopiperazines (2–6) and eleven other known compounds, including one hemi-cycline (10), three aromatic derivatives (11–13), one sesquiterpene (14) and three sterols (15–17). The isolated compounds were screened for anticancer and anti-pathogenic bacterial and fungal activities. Based on this work, Xylaria cf. cubensis SWUF08-86 has proven to be a diverse secondary metabolites producer. |
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| Keywords: | Xylariaceae Xylaria cf cubensis secondary metabolites amino amidine cyclic dipeptide |
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