Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent |
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| Authors: | Ana Carolina de C Correia Tamyris F Ferreira Italo Rossi R Martins Cibério L Macêdo Fabio de S Monteiro Vicente Carlos O Costa |
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| Institution: | Center for Health Sciences (CCS), Federal University of Paraíba (UFPB), Campus I, 58.051-970, PO Box 5009, Jo?o Pessoa, Paraíba, Brazil |
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| Abstract: | Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as ‘pimenteira da terra’, and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729 μg/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27–729 μg/mL) inhibited carbachol or histamine-induced phasic contractions (1 μM) in a significant and concentration-dependent manner. In addition, XL-OE (81 μg/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration. |
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| Keywords: | Annonaceae smooth muscle antispasmodic calcium essential oil |
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